Description
Buy 251-NBOME/N-BOMB Online
Buy 251-NBOME/N-BOMB for Sale Online. 25I-NBOMe (2C-I-NBOMe, Cimbi-5, Smiles, and frequently abbreviated “25I”) is a synthetic hallucinogen used in biochemistry research to map the brain’s utilization of the type 2A serotonin receptor; it is also occasionally taken recreationally. It is the most well-known member of the 25-NB family and a derivative of the 2C-I family of substituted phenethylamines.
It was discovered in 2003 at the Free University of Berlin by chemist Ralf Heim, who reported his results in his doctoral dissertation. Subsequently, a team headed by David Nichols at Purdue University studied the chemical. Cimbi-5 was produced and verified as a radiotracer for positron emission tomography (PET) in Copenhagen.
As the first complete agonist PET radioligand for the 5-HT2A receptor, [11C]-CIMBI-5 shows promise as a more functional marker of these receptors, especially in conditions of high affinity. The street and media monikers for this drug include “N-Bomb,” “Solaris,” “Smiles,” and “Wizard,” but it is sometimes marketed falsely as LSD. Multiple fatalities have been linked to the substance as a result of its physical side effects and overdose danger. Due to an absence of studies, its long-term toxicity is unclear.
Buy 25 I-NBOMe for sale
- Formula: C18H22INO3
- CAS number of substance:919797-19-6
- The molar mass of the substance:427.28 g/mol
- Purity of the preparation: More than 99%
- Full chemical name:2-(4-iodo-2,5-dimethoxy phenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
- Other names:2C-I-NBOMe, Combi-5
25 I-NBOME For Sale
25i-NBOMe, a psychedelic drug that is completely legal and a member of the 2C family, is readily mistaken with LSD. The effects of this chemical are very potent, even at low dosages, and a very tiny quantity may be used to produce a huge number of doses. If you’re searching for a typical dosage, 200 to 600 micrograms should be sufficient to induce a response.
The effects of 25i-NBOMe persist between 6 and 10 hours and provide a variety of advantages. 25i-NBOMe induces a pleasant sensation of euphoria throughout the body with psychedelic images similar to those of LSD, but less intensely. It even alters your perception of colors and might really improve your mood! As a result, it may be an effective treatment for moderate depression.
Moreover, it provides both physical and cerebral stimulation and enhances both creative and associative thinking. It is also believed that 25i-NBOMe may alter your perception of music, providing you with a whole new experience with your favorite tunes, and that it boosts your sentiments of love and compassion.
Be mindful of how much and how often you take it, or you won’t be able to feel the same results (or you’ll need to use much more). It’s safe, legal in every nation, and a delightful experience for individuals of all ages, whether you’re intending to get 25i-NBOMe for inspiration or you’re simply seeking for a little entertainment on a dull day.
Recreational use
Despite being discovered in 2003, 25I-NBOMe did not become a popular recreational drug until 2010, when it was initially offered by vendors specialized in the distribution of designer medications. In slang, the name of the chemical is sometimes abbreviated to “25I” or simply “N-Bomb.” A 2014 study revealed that 25I-NBOMe was the most popular member of the NBOMe series. Case reports of 25I-NBOMe intoxication, with or without analytic proof of the substance in the body, were rising in frequency in the medical literature by 2013.
25I-NBOMe is largely believed to be inert when administered orally; yet, oral overdoses have been seen. Common administration methods include sublingual, buccal, and intranasal. For sublingual and buccal administration, 25I-NBOMe is often applied on blotter paper sheets, of which tiny parts (tabs) are retained in the mouth to permit absorption via the oral mucosa. There have been instances of intravenous injection of 25I-NBOMe solution and smoking the powdered version of the medication.
25I-NBOMe blotters are commonly misrepresented or misidentified as LSD blotters because to their strength and significantly cheaper cost than so-called classical or conventional psychedelics.
Even modest amounts of 25I-NBOMe may generate a substantial number of blotters. Individual dosages of 25I-NBOMe would be imported in bulk (e.g., 1 kilogram containers) and resold for a substantial profit.
Dosage
25I-NBOMe is potent, being active in sub-milligram doses. A common dose of the hydrochloride salt is 600–1,200 μg. The UK Advisory Council on the Misuse of Drugs states that a common dose is between 50 and 100 μg, although other sources indicate that these figures are incorrect; Erowid tentatively suggests that the threshold dosage for humans is 50–250 μg, with a light dose between 200–600 μg, a common dose at 500–800 μg, and a strong dose at 700–1500 μg.
At this level of potency, it is not possible to accurately measure a single dose of 25I-NBOMe powder without an analytical balance, and attempting to do so may put the user at significant risk of overdose. There is a high risk of overdose due to the small margin between a high-dose and an over-dose, which is not a risk with the similar drug LSD. One study has shown that 25I-NBOMe blotters have ‘hotspots’ of the drug and the dosage is not evenly applied over the surface of the paper, which could lead to overdose.
Effects
25I-NBOMe effects usually last 6–10 hours if taken sublingually, or buccally (between gum and cheek). When it is insufflated (snorted), effects usually last 4–6 hours.
25I-NBOMe has similar effects to LSD, though users report more negative effects while under the influence and more risk of harm following use as compared to the classical psychedelics.
Case reports of seven British males who presented to an emergency room following analytically confirmed 25I-NBOMe intoxication suggest the following potential adverse effects: “tachycardia (n = 7), hypertension (4), agitation (6), aggression, visual and auditory hallucinations (6), seizures (3), hyperpyrexia (3), clonus (2), elevated white blood cell count (2), elevated creatine kinase (7), metabolic acidosis (3), and acute kidney injury (1).”[15]
25I-NBOMe can be consumed in liquid, powder or paper form and can be snorted, injected, mixed with food, or smoked, but sublingual administration is most common.
Toxicity
Recreational use of 25I-NBOMe carries a significant risk of both pharmacological and behavioral toxicity. 25I-NBOMe is a relatively new substance, and little is known about its pharmacological risks or its interaction with other substances, although multiple deaths have occurred while under the effects of 25I-NBOMe and other drugs. The LD50 has not yet been determined. The long-term toxicity of 25I-NBOMe is unknown due to lack of research.
NBOMe chemicals, including 25I-NBOMe, frequently cause tachycardia (rapid heart rate), hypertension (high blood pressure), and vasoconstriction (which reduces blood flow). These physical symptoms can cause significant risks to health, especially when the user has underlying health issues or has taken a combination of drugs.
25I-NBOMe presumably exhibits functional selectivity at the 5HT2A receptor similar to other phenethylamine hallucinogens, activating the Phospholipase A2 signal cascade, which is responsible for the release of Thromboxane A2, triggering blood platelet aggregation. Excessive concentrations of TXA2 could lead to thrombosis, which when coupled with 25I-NBOMe’s vasoconstrictive effect, is a major risk factor for cardiac ischemia, a dangerous condition the symptoms of which are present in several toxicological reports.
One 16-year-old was studied in 2017 after reporting seizures attributed to 25I-NBOMe usage, which after 18 months culminated in progressive left-sided weakness, ataxia, facial droop, executive dysfunction. An MRI revealed the patient to have brain damage revealed by an MRI to be bilateral leukoencephalopathy concurrent with symptoms of serotonin syndrome. According to the researchers ‘patients with 25I-NBOMe toxicity frequently display signs of serotonin syndrome’.
Attributed deaths
Reports of deaths and significant injuries have been attributed to the use of 25I-NBOMe, prompting some governments to control its possession, production, and sale. The website Erowid states that 25I-NBOMe is extremely potent and should not be snorted, and that the drug “appears to have led to several deaths in the past year.” Several non-fatal overdoses requiring prolonged hospitalization have also been reported.
As of August 2015, 25I-NBOMe has reportedly led to at least 19 overdose deaths in the United States. In June 2012, two teens in Grand Forks, North Dakota and East Grand Forks, Minnesota fatally overdosed on a substance that was allegedly 25I-NBOMe, resulting in lengthy sentences for two of the parties involved and a Federal indictment against the Texas-based online vendor. A 21-year-old man from Little Rock, Arkansas died in October 2012 after taking a liquid drop of the drug nasally at a music festival. He was reported to have consumed caffeinated alcoholic beverages for “several hours” beforehand. It is unclear what other drugs he may have consumed, as autopsies generally do not test for the presence of research chemicals. In January 2013, an 18-year-old in Scottsdale, Arizona, died after consuming 25I-NBOMe sold as LSD; a toxicology screening found no other drugs in the person’s system. The drug is the suspected cause of death in another Scottsdale, Arizona, incident in April 2013. It is also cited in the death of a 21-year-old woman in August 2013 and the death of a 17-year-old in Minnesota in January 2014, as well as the death of a 15-year old in Washington in September 2014.
25I-NBOMe has been implicated in multiple deaths in Australia. In March 2012, a man in Australia died from injuries sustained by running into trees and power poles while intoxicated by 25I-NBOMe. A Sydney teenager jumped off a balcony to his death on June 5, 2013 while on 25I-NBOMe.
25I-NBOMe has been linked to a major case on January 20, 2016 in Cork, Republic of Ireland, which left six teenagers hospitalized, one of whom later died. At least one of the teenagers suffered a cardiac arrest, according to reports, along with extreme internal bleeding. At least one suicide, and two attempted suicides leading to hospitalisation, have occurred while under the effects of 25I-NBOMe.
Pharmacology
| Receptor | Kd (nM) | ± |
|---|---|---|
| 5-HT2A | 0.044 | |
| 5-HT2B | 231 | 73 |
| 5-HT2C | 2 | |
| 5-HT6 | 73 | 12 |
| μ-opioid | 82 | 14 |
| κ-opioid | 288 | 50 |
| H1 | 189 | 35 |
25I-NBOMe acts as a highly potent full agonist for the human 5-HT2A receptor,[35][37] with a dissociation constant (Kd) of 0.044 nM, making it some sixteen times the potency of 2C-I itself at this receptor. A radiolabelled form of 25I-NBOMe can be used for mapping the distribution of 5-HT2A receptors in the brain.
25I-NBOMe induces a head-twitch response in mice which is blocked completely by a selective 5-HT2A antagonist, suggesting its psychedelic effects are mediated by 5-HT2A. This study suggested that 25I-NBOMe is approximately 14-fold more potent than 2C-I in-vivo. While in-vitro studies showed that N-benzyl derivatives of 2C-I were significantly increased in potency compared to 2C-I, the N-benzyl derivatives of the related compound DOI were inactive.
25I-NBOMe also has weaker interactions with multiple other receptors. Kd values for interaction with the following targets were greater than 500 nM: 5-HT1A, D3, H2, 5-HT1D, α1A adrenergic, δ opioid, serotonin uptake transporter, 5-HT5A, 5-HT1B, D2, 5-HT7, D1, 5-HT3, 5-HT1E, D5, muscarinic M1-M5, H3, and the dopamine uptake transporter.
Chemistry
Like other 2C-X-NBOMe molecules, 25I-NBOMe is a derivative of the 2C family of phenethylamines described by chemist Alexander Shulgin in his book PiHKAL. Specifically, 25I-NBOMe is an N-benzyl derivative of the phenethylamine molecule 2C-I, formed by adding a 2-methoxybenzyl (BnOMe) onto the nitrogen (N) of the phenethylamine backbone. This substitution significantly increases the potency of the molecule.
Analogues
Analogues and derivatives of 2C-I:
25I-NB*:
- 25I-NBF
- 25I-NBMD
- 25I-NB34MD
- 25I-NBOH
- 25I-NBOMe (NBOMe-2CI)
- 25I-NB3OMe
- 25I-NB4OMe
Synthesis
25I-NBOMe is usually synthesised from 2C-I and 2-methoxybenzaldehyde, via reductive alkylation. It can be done stepwise by first making the imine and then reducing the formed imine with sodium borohydride, or by direct reaction with sodium triacetoxyborohydride.
Society and culture
Legal status
Australia
25I-NBOMe was explicitly scheduled in Queensland drug law in April 2012, and in New South Wales in October 2013, as were some related compounds such as 25B-NBOMe. The Australian federal government has no specific legislation concerning any of the N-benzyl phenethylamines.
Canada
As of October 31, 2016; 25I-NBOMe is a controlled substance (Schedule III) in Canada.
China
As of October 2015 25I-NBOMe is a controlled substance in China.
European Union
In September 2014 the European Union implemented a ban of 25I-NBOMe in all its member states.
Israel
Israel banned 25I-NBOMe in 2013.
Russia
Russia was the first country to pass specific regulations on the NBOMe series. All drugs in the NBOMe series, including 25I-NBOMe, became illegal in Russia in October 2011.
United Kingdom
This substance is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act
United States
On Nov 15, 2013, the DEA added 25I-NBOMe (and 25C-, and 25B-NBOMe) to Schedule I using their emergency scheduling powers, making those NBOMe compounds “temporarily” in Schedule I for 2 years. In November 2015, the temporary scheduling was extended for an additional year while permanent scheduling was arranged. 25I-NBOMe, 25B-NBOMe and 25C-NBOMe are currently Schedule 1 Substances according to 21 CFR 1308.11(d).
Romania
In 2011, Romania banned all psychoactive substances.
Serbia
25I-NBOMe was put on the list of prohibited substances in March 2015.
Sweden
The Riksdag added 25I-NBOMe to Narcotic Drugs Punishments Act under Swedish schedule I (“substances, plant materials and fungi which normally do not have medical use”) as of August 1, 2013, published by Medical Products Agency (MPA) in regulation LVFS 2013:15 listed as 25I-NBOMe, and 2-(4-jodo-2,5-dimetoxifenyl)-N-(2-metoxibensyl)etanamin.[51]
Taiwan[edit]
Following the European rule from 2014, 25I-NBOMe was put in class 4 of prohibited substances.[52]
Brazil[edit]
All drugs in the NBOMe family, including 25I-NBOMe, are illegal.
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